Drug is used primarily in pediatric patients.
A pure sedative hypnotic with no analgesic properties. It may produce a state of disinhibition with an agitated response to noxious stimuli. It is used as an adjunct for painful therapeutic procedures. Most effective in children less than 4 years of age. See table for more information.
Dosage and Route of Administration:
Oral: 25-100 mg/kg up to 1g dose (max of 2g in 2 divided doses)
Onset: 15-30 Minutes
Peak effect: 30-60 minutes
Duration: 60 minutes (residual sedation may persist for 10 or more hours in toddlers, but 20 hours or more in neonates)
Desaturation, respiratory depression and airway obstruction, agitation, ataxia, vomiting, cardiac arrhythmias.
Increased risk of direct and indirect hyperbilirubinemia and kernicterus in newborns.
Metabolic acidosis with repeat administration particularly in neonates.
- Not recommended for repeat use in neonates.
- Single use will produce prolonged sedation in preterm infants and full-term infants< 1 month of age.
- Cautious use with other sedatives or opioids – may increase the risk of respiratory complications.
- May alter the rate of metabolism of warfarin or warfarin-related anticoagulants.
Preterm and term neonates (repeat dosing).
Should not be used on a chronic basis
Patients with significant hepatic or renal disease
Patients with cardiac dysrhythmias
Patients who have previously exhibited an idiosyncrasy or hypersensitivity to the drug
Oral dose contraindicated in patients with gastritis
Patients with Porphyria
- None Avaliable