Diprivan (Propofol)


Propofol Classification:

Sedative hypnotic. Produces rapid hypnosis with minimal excitation.




Onset of Action

Peak Effect

Duration of Action


40 seconds

1 minute

5-10 minutes


Adult dose

25 – 50mg (0.5 – 1 mg/kg) IV, administered in 10 mg increments over several minutes. 

  • Pain on injection is decreased with IV lidocaine, 0.1 mg/kg, added to the diprivan emulsion. 
  • Strict aseptic technique must be maintained in handling, as diprivan is preservative free and will support bacterial growth. 
  • Diprivan injection should be prepared for single patient use only, just prior to the initiation of each procedure. Discard after opened for 6 hours.


Pediatric dose:

0.5 – 1.0mg/kg infused slowly and titrated to desired effect.


Adverse Reactions:

  • Respiratory effects – respiratory depression, apnea, hiccup, bronchospasm, laryngospasm
  • Cardiovascular effects –hypotension, arrhythmia, tachycardia, bradycardia, hypertension
  • CNS effects – headache, dizziness, euphoria, myoclonic/clonic movement, seizures, and sexual illusions.
  • GI effects– nausea, vomiting, abdominal cramps
  • Special considerations – this drug must be titrated to effect and administered slowly to prevent the occurrence of adverse reactions.  Reduce dose in elderly, hypovolemic, and high-risk patients.  Potentiation occurs when combined with narcotic analgesics and CNS depressants.



There is no pharmacologic reversal agent for Propofol.

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